A list of the known protective variants
@erictopol
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Protective Genomic Variants Shield Some Alzheimer’s Mutation Carriers
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Why do some people who have mutations of familial Alzheimer's do not get the disease?
They have protective genomic variants.
A first-rate review @TheLancetNeuro https://
thelancet.com/journals/laneu
r/article/PIIS1474-4422(25)00116-4/abstract
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Generative AI and Chatbots for Mental Health Support
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Where are we with generative A.I./chatbots to support mental health? @JohnTorousMD and I provide a concise summary of progress and what's needed @TheLancet https://
thelancet.com/journals/lance
t/article/PIIS0140-67362501237-1/fulltext
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National Academies releases AI code of conduct for healthcare
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Our new @theNAMedicine report on #AI in medicine and healthcare, open-access https://
nap.nationalacademies.org/catalog/29087/
an-artificial-intelligence-code-of-conduct-for-health-and-medicine
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Healthcare professionals’ misconceptions about dementia and disease
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"ADI’s 2024 World Alzheimer Report found that 65% of health-care professionals surveyed globally thought that dementia was a normal part of ageing — not a condition caused by a disease" https://
nature.com/articles/d4158
6-025-01768-8
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Open Foundation Model Outperforms AI for Chest X-ray Diagnosis
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A new open foundation model for chest X-ray and thoracic diagnoses that outperforms previous A.I. especially for rare diseases @Nature https://
nature.com/articles/s4158
6-025-09079-8
… https://
nature.com/articles/d4158
6-025-01525-x
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SGLT2 Drugs Show Senolytic Properties for Healthspan Extension
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The sodium-glucose transporter (SGLT2) drugs for diabetes have some senolytic properties (getting rid of senescent cells) and better than expected health outcomes. They are candidate drugs for extending healthspan (as also reviewed in SUPER AGERS)
by @AlexLJanin -
AI Shifts Cardiovascular Disease Prevention Focus to Atrial Fibrillation
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The shift in cardiovascular disease. From reduction of heart attacks, coronary artery disease, and strokes to more atrial fibrillation ("the most common cardiovascular problem")
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Breakthrough Blood Test for Alzheimer’s Disease Prediction
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I recently reviewed this impressive body of data for predicting Alzheimer's and why I consider it a breakthrough, a term I don't use lightly https://
erictopol.substack.com/p/the-breakthr
ough-blood-test-for-alzheimers
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