Epigenetic (methylation, biological) age is associated with increased risk of dementia and brain structural changes (including atrophy). From UK Biobank's 280,000 participants, ~4,800 cases of dementia over 14-year follow-up https://
neurology.org/doi/10.1212/WN
L.0000000000213616
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@erictopol
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Epigenetic Age Predicts Dementia Risk Using AI Analysis
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AI Research Identifies Colon Cancer Patterns in Young Adults
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And @TheEconomist today, tying this work with colon cancer in the young
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AI Test Predicts Alzheimer’s Onset with Lifestyle Factors
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Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground -
p-Tau217 Blood Test Breakthrough for Alzheimer’s Disease Prevention
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p-Tau217 is a breakthrough blood test that can accurately predict and may help prevent Alzheimer's disease. https://
erictopol.substack.com/p/the-breakthr
ough-blood-test-for-alzheimers
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Here's the rundown on it. Free, open-access. -
Blood Test Biomarker Enables Early Parkinson’s Disease Detection
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A blood test biomarker for early detection of Parkinson's disease when there are no symptoms
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Breakthrough brain mapping and genome sequencing advances announced
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A huge day for mapping in life science!
—the mammalian brain, most extensive yet https://
nature.com/articles/s4158
6-025-08790-w
… @AllenInstitute —a comprehensive map of the human cell going sub-cellular https://
nature.com/articles/s4158
6-025-08878-3
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—complete ape genomes https://
nature.com/articles/s4158
6-025-08816-3
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AI Improves Diagnostic Accuracy Clinical Performance Nature
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2 important papers @Nature today indicate the potential for #AI to improve diagnostic accuracy and overall clinical performance for patient management and interactions @GoogleDeepMind @vivnat @danmcduff @taotu831 @alan_karthi https://
nature.com/articles/s4158
6-025-08866-7
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GLP-1 and SGLT2i Drugs Show Promise Against Alzheimer’s Disease
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In people with diabetes, GLP-1 and SGLT2i drugs were associated with less Alzheimer's disease and related dementias https://
jamanetwork.com/journals/jaman
eurology/fullarticle/2831976
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FountainLife APEX Membership Added at $19,500 Annually
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Adding @fountainlife_hq (thanks to @erikbryn for prodding my memory) at $19,500 per year for its "APEX" membership. Also revised in the accompanying text
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Business of promoting longevity: critical analysis and market trends
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Here's a Table summary, the foundation for critique in the essay
Link https://
erictopol.substack.com/p/the-business
-of-promoting-longevity
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