"ADI’s 2024 World Alzheimer Report found that 65% of health-care professionals surveyed globally thought that dementia was a normal part of ageing — not a condition caused by a disease" https://
nature.com/articles/d4158
6-025-01768-8
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@erictopol
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Healthcare professionals’ misconceptions about dementia and disease
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Open Foundation Model Outperforms AI for Chest X-ray Diagnosis
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A new open foundation model for chest X-ray and thoracic diagnoses that outperforms previous A.I. especially for rare diseases @Nature https://
nature.com/articles/s4158
6-025-09079-8
… https://
nature.com/articles/d4158
6-025-01525-x
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SGLT2 Drugs Show Senolytic Properties for Healthspan Extension
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The sodium-glucose transporter (SGLT2) drugs for diabetes have some senolytic properties (getting rid of senescent cells) and better than expected health outcomes. They are candidate drugs for extending healthspan (as also reviewed in SUPER AGERS)
by @AlexLJanin -
AI Shifts Cardiovascular Disease Prevention Focus to Atrial Fibrillation
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The shift in cardiovascular disease. From reduction of heart attacks, coronary artery disease, and strokes to more atrial fibrillation ("the most common cardiovascular problem")
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Breakthrough Blood Test for Alzheimer’s Disease Prediction
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I recently reviewed this impressive body of data for predicting Alzheimer's and why I consider it a breakthrough, a term I don't use lightly https://
erictopol.substack.com/p/the-breakthr
ough-blood-test-for-alzheimers
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FDA Approves Blood Test for Alzheimer’s Disease Detection
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p-tau217 has been available in the US for the past ~2 years (Quest and LabCorp) the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems, by @PamBelluck gift link https://
nytimes.com/2025/05/21/hea
lth/blood-test-alzheimers.html?unlocked_article_code=1.J08.pzt5.8WROiJULocKT&smid=url-share
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Blood biomarker AI predicts Alzheimer’s in cognitively unimpaired middle-aged adults
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Predicting Alzheimer's in people who are cognitively unimpaired in middle-age via blood tests p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid new publication today https://
thelancet.com/journals/ebiom
/article/PIIS2352-3964(25)00185-9/fulltext
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AI Biomarkers Track Muscle Strength Loss in Alzheimer’s Disease
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p-tau217 and other biomarkers for Alzheimer’s disease also tracked with loss of muscle strength in ~2,000 participants followed 12 years (Figures hand grip and chair-to-stand) https://
thelancet.com/journals/lanhl
/article/PIIS2666-7568(25)00034-0/fulltext
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