p-tau217 has been available in the US for the past ~2 years (Quest and LabCorp) the p-Tau217/Aβ42 ratio test (Lumipulse) was just approved by FDA last week for people with memory problems, by @PamBelluck gift link https://
nytimes.com/2025/05/21/hea
lth/blood-test-alzheimers.html?unlocked_article_code=1.J08.pzt5.8WROiJULocKT&smid=url-share
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@erictopol
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FDA Approves Blood Test for Alzheimer’s Disease Detection
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Blood biomarker AI predicts Alzheimer’s in cognitively unimpaired middle-aged adults
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Predicting Alzheimer's in people who are cognitively unimpaired in middle-age via blood tests p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid new publication today https://
thelancet.com/journals/ebiom
/article/PIIS2352-3964(25)00185-9/fulltext
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AI Biomarkers Track Muscle Strength Loss in Alzheimer’s Disease
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p-tau217 and other biomarkers for Alzheimer’s disease also tracked with loss of muscle strength in ~2,000 participants followed 12 years (Figures hand grip and chair-to-stand) https://
thelancet.com/journals/lanhl
/article/PIIS2666-7568(25)00034-0/fulltext
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Single-cell DNA replication tracking reveals cancer heterogeneity patterns
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New @Nature
— Eric Topol (@EricTopol) 21 mai 2025
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancerhttps://t.co/5S2QIorb0A pic.twitter.com/zZFYmvII0uNew @Nature An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer https://
nature.com/articles/s4158
6-025-08986-0#MOESM8
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AI System Generates Protein Design from Natural Language
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Hey A.I., make me a protein @ewencallaway @Nature
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Patient Super Ager Featured in Wellbeing Book Discussion
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Join us tomorrow. Free registration for. Virtual access Meet my patient Mrs L. R. featured in the book, a Wellderly, Super Ager
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Brain Glymphatics System Crucial for Neurodegeneration Prevention
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The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @jonykipnis @ImmunityCP
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11000 Blood Proteins Analyzed Using AI Healthcare
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It’s in here https://
erictopol.substack.com/p/what-can-110
00-proteins-in-our-blood
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AI-Powered Heart Aging Clock Distinguishes Healthy from Unhealthy
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Along with prior validation of a heart organ proteomic clock to determine its pace of aging in an individual, there's a heart MRI clock, distinguishing healthy vs unhealthy aging
open-access https://
academic.oup.com/ehjopen/articl
e/5/3/oeaf032/8098121?login=false
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