New @Nature Our self-direct (auto-)antibodies shape response to cancer immunotherapy. Yet another reason we need an immunome to optimize cancer treatment (and prevention)
@erictopol
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Microbiome Sixth Sense Regulates Eating Behavior Via Gut-Brain
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The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model
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Agentic AI Predicts Biological Aging and Health Outcomes
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Agentic A.I. to predict body-wide and organ specific biological aging with associated health outcomes
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AI Predicts Coronary Artery Disease Risk More Accurately
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We can predict a person's risk of coronary artery disease better than ever before. Cover of new @NatureMedicine regarding our @ScrippsRTI @scrippsresearch recent paper @ATorkamani https://
nature.com/articles/s4159
1-025-03648-0
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NIH Budget Cuts Threaten Medical Research and Young Scientists
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And today's @latimes coverage, by @niamh_ordner https://
latimes.com/science/story/
2025-07-06/nih-budget-cuts-threaten-the-future-of-medical-research-and-young-scientists
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US Biomedical Research Faces Massive Funding Cuts
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Summary Table of the massive defunding of biomedical research in the United States https://
nytimes.com/interactive/20
25/06/30/opinion/hhs-cuts-harming-american-health.html
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New Anti-Aging Evidence for Estrogen Discovered
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Link https://
erictopol.substack.com/p/new-anti-agi
ng-evidence-for-estrogen
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Data Context Problems: Critical AI Challenge
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Exactly. That's a big problem in context with the data
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Polygenic Risk Scores Prove Critical for Heart Disease Prediction
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Hardly anyone knows their polygenic risk score for heart disease and here's yet another study to show how important it is for predicting a person's risk.
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Human Somatic Mutation Mosaicism Exceeds Quadrillions
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We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @Nature https://
nature.com/articles/s4158
6-025-09096-7
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