B. Chronic PM2.5 exposure in the mouse model led to brain atrophy, cognitive deficit and alpha-synuclein pathology in other organs
@erictopol
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Covid-19 Accelerates Vascular Aging in Women: Study
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Covid accelerates vascular aging
An 18-country, 38-center study of ~2,000 participants
—Effect predominantly in women, adding 5 years of vascular aging (EVA)
—Seen with non-hospitalized and mild-moderate Covid
—Reversible in some at 1-year; vaccination link to protection -
Diabetes Platelet Hyperactivity Mechanism SEC61B Calcium Balance
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Discovery of a mechanism for the increased risk of arterial blood clots in people with diabetes: platelet hyperactivity mediated by SEC61B, calcium balance inside these cells @jclinicalinvest https://
jci.org/articles/view/
184597
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Genome editing reaches the brain: breakthrough in neurological disease treatment
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We've seen how human genome editing is working for disease- causing mutations in the blood, liver and eye. The brain was considered to be an exceptionally difficult target. That's changing @Nature by @heidiledford https://
nature.com/articles/d4158
6-025-02578-8
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AI aging analysis reveals mortality risk patterns
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its pace of aging is connected with higher risk of mortality
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Blood vessels show aging first across thirteen organs studied
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Through comprehensive proteomics, blood vessels were the organ first to show aging, of 13 organs assessed, in a cohort of 76 individuals aged 14 to 68 years, with an aging inflection around age 50 https://
cell.com/cell/abstract/
S0092-8674(25)00749-4?_returnURL=httpslinkinghub.elsevier.comretrievepiiS0092867425007494showalltrue
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AI-Powered Proteome Clocks Map Human Aging Across Lifespan
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The human proteome and organ age clocks across the lifespan, a tour de force report @CellCellPress https://
cell.com/cell/abstract/
S0092-8674(25)00749-4
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Ingestible Pill Innovation Monitors Gut Inflammation
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A simple ingestible pill innovation for monitoring inflammation of the gut https://
cell.com/device/fulltex
t/S2666-9986(25)00178-4?_returnURL=httpslinkinghub.elsevier.comretrievepiiS2666998625001784showalltrue
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Economics of superintelligence raises concerns about AI benefits
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It doesn't make superintelligence look good 😉 https://
economist.com/leaders/2025/0
7/24/the-economics-of-superintelligence
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Why We Need an Immunome: Personalized Health Innovation
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why we need an immunome https://
erictopol.substack.com/p/why-we-need-
an-immunome
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