Building on more remarkable work by @arcinstitute to markedly expand the capabilities for human genome editing ("CRISPR 3.0"). Watch our conversation just after their discovery of Bridge RNAs https://
erictopol.substack.com/p/patrick-hsu-
a-trailblazer-in-digital
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@erictopol
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CRISPR 3.0: Bridge RNAs Expand Human Genome Editing Capabilities
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Generative AI Clinical Reasoning Models Fail Under Scrutiny
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The performance of generative A.I. models for clinical reasoning are not holding up to increased scrutiny https://
arxiv.org/abs/2509.18234 @MSFTResearch https://
ai.nejm.org/doi/full/10.10
56/AIdbp2500120
… @NEJM_AI @AdamRodmanMD @LiamGMcCoy -
GLP-1 Drugs Show Different Weight Loss Effects in Diabetics
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More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose https://
nature.com/articles/s4136
6-025-01920-4
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AI Prior Authorization Program Raises Healthcare Concerns
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What could possibly go wrong? https://
kffhealthnews.org/news/article/a
i-medicare-prior-authorization-trump-pilot-program-wiser/?utm_campaign=KHNFirstEdition&utm_medium=email&_hsenc=p2ANqtz–ea5c2MUpa_mWlasUTiUurxkRHR10Fkkw0G_9uhOnyDfAq-GCbYjieDw97IBZSdkjhkogBXEOvkQL-Y2c03U0I-t64nw&_hsmi=382232457&utm_content=382232457&utm_source=hs_email
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Gut Microbiome Could Extend Ovarian Function Experimentally
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The potential to extend ovarian functionality via the gut microbiome, as shown in the experimental model
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Maria Branyas Longevity Genes Microbiome Research Study
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Here she is https://
nytimes.com/2025/09/24/hea
lth/maria-branyas-longevity-genes-microbiome.html?searchResultPosition=1
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Primary Prevention: Future of Medicine Through AI
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The future of medicine is about preventing the major diseases from ever showing up. Primary prevention. https://
erictopol.substack.com/p/dawn-of-a-ne
w-era-of-primary-prevention
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AI Identifies Precursor Immune Features for Rheumatoid Arthritis Prevention
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The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective -
Genome Editing T Cells Boost Cancer Immune Response
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Elegant ways to rev up the immune system vs cancer keep expanding: Genome editing of engineered T cells https://
nature.com/articles/s4158
6-025-09507-9
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Billionaires Fund Aging Reversal Research and Longevity
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The billionaires funding aging reversal.
When they were young they wanted to be rich. When they were rich, they wanted to be young. @shaneshifflett @AmyDMarcus @AlexLJanin https://
wsj.com/health/wellnes
s/billionaires-longevity-health-04dd205c?st=zAGX85&reflink=desktopwebshare_permalink
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