On GPT-5 and medicine, status summary https://
nature.com/articles/s4159
1-025-04008-8
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@erictopol
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GPT-5 and Medicine: Status Summary from Nature
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Breakthrough Blood Test Predicts Alzheimer’s Disease Progression
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The single blood test that "not only indicated
how advanced the disease was but also helped to predict its [Alzheimer's disease] progression." https://
nature.com/articles/s4358
7-025-00951-w
… and more here https://
erictopol.substack.com/p/the-breakthr
ough-blood-test-for-alzheimers
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AI and physician de-skilling: Lancet analysis of solutions
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Will A.I. lead to de-skilling of physicians?
And if so what can be done to preempt it? @tberzin and I address this in a new @TheLancet piece https://
thelancet.com/journals/lance
t/article/PIIS0140-6736(25)02075-6/abstract
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Genome Sequencing Identifies Cancer Pathogenic Variants in 5% Population
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At least 5% of people have cancer pathogenic gene variants via genome sequencing , a consistent finding among several large cohorts https://
jamanetwork.com/journals/jama/
fullarticle/2840089i
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AI Identifies Seven Organ Clocks Using MRI Imaging
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Identifying and validating 7 organ clocks based on MRI
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Record ultra-rapid genome sequencing AI interpretation for critical patients
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A new world record for ultra rapid whole genome sequencing and interpretation for critically ill individuals @NEJM <4hrs
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Genome editing advances for mitochondrial disease treatment
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Towards genome editing for mitochondrial diseases https://
nature.com/articles/d4158
6-025-03307-x
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Stem cells show promise treating Parkinson’s disease in clinical study
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More progress with stem cells treating #Parkinsons disease, as seen by motor improvements in a dose-escalating study of 12 patients https://
cell.com/cell/fulltext/
S0092-8674(25)01041-4
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Preparing Physicians for the Generative AI Era
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A concise viewpoint on how physicians can prepare for the generative A.I. era https://
jamanetwork.com/journals/jamai
nternalmedicine/fullarticle/2840192
… @JAMAInternalMed -
Gene therapy restores hearing in deaf children via one-shot treatment
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New @NEJM One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing http://
nejm.org/doi/full/10.10
56/NEJMoa2400521
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