The burial and the excavation @JAMA_current commentary today https://
jamanetwork.com/journals/jama/
fullarticle/2848376
…
(what I wrote about in Deep Medicine, 2019)
@erictopol
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AI in Medicine: Burial and Excavation Commentary
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Polygenic Risk Scores Cardiovascular AI Clinical Implementation Gap
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Polygenic risk scores for 8 cardiovascular traits in both @MassGenBrigham and @AllofUsResearch
—superimposable— strongly indicate risk. Yet still not implemented in clinical practice https://
jacc.org/doi/10.1016/j.
jacc.2026.03.035
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Neurons Hijacking in Cancer: Neural Fibers Slow Melanoma Growth
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A twist in cancer neuroscience with many studies showing hijacking of neurons to promote cancer—melanoma growth slowed by nerve fibers in skin https://
cell.com/neuron/fulltex
t/S0896-6273(26)00285-0
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AI Detects Pancreatic Cancer Better Than Radiologists
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An AI that detects occult pancreatic cancer better than radiologists (73 vs 39%) via CT with external validation https://
gut.bmj.com/content/early/
2026/04/22/gutjnl-2025-337266
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AI Mental Health Support Shows Promise in Real-World Study
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Some AI progress for mental health support seen in a real-world prospective study (<-there are few of these)
"In a real-world, two-arm prospective study, resident psychiatrists assisted by PsychFound demonstrated higher consultation quality, higher diagnostic accuracy, more -
TED Talk on Retinal Information Processing in AI Vision
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I gave a @TEDTalks on this topic, and the richness of information from the retina keeps expanding
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AI Foundation Model Detects Multiple Diseases from Retinal Photos
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What superhuman vision can detect from the retinal photo, which human eyes cannot, is stunning. A new foundation AI model screening for diabetes hypertension, hyperlipidemia, gout, osteoporosis, and thyroid disease @NatureMedicine https://
nature.com/articles/s4159
1-026-04359-w
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Gene Therapy Eye Trial Begins: First Clinical Test Underway
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We don't even know if it will work in the eye, the first small pilot trial yet to start, by @heidiledford @Nature https://
nature.com/articles/d4158
6-026-01024-7
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Accidental Medical Discoveries: Serendipity in Healthcare Innovation
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Big innovations that were discovered by mistake!
Nice summary by @Zlatimeyer Can add coronary angiography by Mason Sones to the list, and many others in medicine.
Gift link https://
wsj.com/business/us-in
ventions-mistake-discovery-8d0ff716?st=WkraPi&reflink=desktopwebshare_permalink
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Obesity’s Epigenetic Impact on Immune System Memory
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The impact oif obesity on the immune system.
Through methylation, obesity imprints memory to CD4+ (helper) T cells, which can last for many years, and promotes immune system dysregulation and inflammation. @emboreports https://
link.springer.com/article/10.103
8/s44319-026-00765-w
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