It's striking. Both the under- and over-use of AI in medicine, by patients and doctors, for where there's evidence and where it doesn't exist
@erictopol
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Study Documents AI Inequalities Among Lower Socioeconomic Americans
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A study of >10,000 Americans documents AI inequalities, lack of awareness and usage among lower SES https://
tandfonline.com/doi/full/10.10
80/1369118X.2026.2652505
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AI Chatbots Yield Lower Quality Symptom Reports Than Physicians
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Symptoms reported to an AI chatbot were of lesser quality than reported to a physician, results of a randomized trial of 500 participants across multiple models https://
nature.com/articles/s4436
0-026-00116-y
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AI-Driven De Novo Protein Design and Nanomachines
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No less, enabling the design de novo proteins, a brilliant review @nature "Over the next five to ten years, we anticipate the design of sophisticated protein nanomachines and materials with functionality ranging far beyond that generated during natural evolution for a wide range
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GenAI Makes Isoleucine Dispensable Rewriting Alphabet of Life
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Not something you'd see everyday—changing the alphabet of life. All of life organisms are are built from 20 amino acids. Now genAI is enabling life to be built with 19 amino acids, making isoleucine dispensable. @ScienceMagazine https://
science.org/doi/10.1126/sc
ience.aeb5171
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AI as Misinformation Tool and Deepfake Threat, Science Magazine
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Twin pieces by @kakape in the new issue @ScienceMagazine on AI, used as a purveyor of misinformation and deep fakes, open-access https://
science.org/content/articl
e/misinformation-researchers-ai-scourge-and-powerful-new-tool
… https://
science.org/content/articl
e/deepfakes-are-everywhere-godfather-digital-forensics-fighting-back
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AI Alone Outperforms Doctors Using AI in Multiple Tasks
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As we have previously noted in multiple studies, an AI model alone outperformed physicians with AI (GPT-4) for multiple tasks @pranavrajpurkar https://
nytimes.com/2025/02/02/opi
nion/ai-doctors-medicine.html
… https://
erictopol.substack.com/p/when-doctors
-with-ai-are-outperformed
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OpenAI o1 Outperforms GPT-4 and Physicians in Clinical Triage
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New @ScienceMagazine The o-1 reasoning model (text only, from @OpenAI
, released, Sept 2024) exceeded performance cf GPT-4 and physicians for clinical vignette management reasoning and in a real-world emergency department assessment for initial triage @AdamRodmanMD -
AI Advances Prediction of Type 1 Autoimmune Diabetes
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A jump in our ability to predict Type 1 autoimmune diabetes should help future preventive strategies @NatureGenet https://
nature.com/articles/s4158
8-026-02571-5
… https://
nature.com/articles/s4158
8-026-02578-y
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Organs Age Differently: Plasma Proteins Track Individual Aging Rates
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Our organs age at a different pace intra-individual, as tracked through plasma proteins. Now confirmed for female reproductive organs @NatureAging https://
nature.com/articles/s4358
7-026-01098-y
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