In people with HFpEF (heart failure with preserved ejection fraction) and severe obesity, there is a heart muscle cell defect with sarcomere hyper-phosphorylation. Besides weight loss, sarcomere enhancers (not yet studied) may help. @ScienceMagazine https://
science.org/doi/10.1126/sc
ience.adz7118
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@erictopol
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Sarcomere Enhancers Show Promise for HFpEF Obesity Treatment
By
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Fraudulent Author Names Discovered in Academic Paper
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all the author names were fraudulent; they had nothing to do with the paper
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AI Discovery of MRSA-Effective Pill Could Transform Treatment
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If AI can find a pill effective vs MRSA that would be big.
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US Biomedical Research Funding Under Political Pressure
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How to stymie biomedical research in the United States
gift link https://
nytimes.com/2026/04/22/sci
ence/trump-nih-funding-research.html?unlocked_article_code=1.dFA.vxP1.VXHgHyzvVhM2&smid=url-share
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OpenAI Launches ChatGPT for Clinicians and HealthBench Professional
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Today @OpenAI introduced ChatGPT for Clinicians, provided free for credentialed HCPs, and HealthBench Professional for benchmarking LLM medical task performance (Figure) https://
openai.com/index/making-c
hatgpt-better-for-clinicians/
… https://
cdn.openai.com/dd128428-0184-
4e25-b155-3a7686c7d744/HealthBench-Professional.pdf
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Rewarding LLM Uncertainty Reduces Hallucinations
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New @Nature To reduce LLM hallucinations they should be rewarded for admitting uncertainty
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AI-Generated Fraudulent Paper: Academic Integrity Crisis Exposed
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This is a FRAUDULENT paper, AI-generated. My name was used as an author and I had nothing to do with it, never saw it until today https://
e-pubmed.co.uk/journals/digit
al-health-implementation/articles/implementation-science-ai-digital-health-systematic-review/
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The "Editors" Angelo Rossi Mori, David Mensah, and Zarnie Khadjesari should be reported. -

CRISPR genome editing accessibility and standard care advancement
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How individualized CRISPR genome editing can go from rare, expensive use to broader accessibility and a standard of care
by @UrnovFyodor and Sadik Kassim @Nature https://
nature.com/articles/d4158
6-026-01243-y
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Sex Chromosomes Impact on Cancer and Neurologic Disease Research
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Our X and Y chromosomes play a bigger part in health than acknowledged, including cancer, autoimmunity, and neurologic conditions. A new @nature feature
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Medical AI Evidence Gap: Improving Patient Care Outcomes
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On the lack of compelling evidence that medical AI is improving patient care, and what to do about it, a @NatureMedicine editorial https://
nature.com/articles/s4159
1-026-04389-4
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