2 new large observational studies show GLP-1 drugs are associated with reduced dementia in people with diabetes —Sweden, vs other drugs for diabetes (Figure) https://
thelancet.com/journals/eclin
m/article/PIIS2589-5370(24)00268-2/fulltext
…
—US Medicare population, vs DPP-4 https://
diabetesjournals.org/diabetes/artic
le/73/Supplement_1/750-P/155861/750-P-Association-of-Glucagon-Like-Peptide-1
…
@erictopol
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GLP-1 Drugs Linked to Reduced Dementia Risk in Diabetic Patients
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Tirzepatide Shows Protection Against Sleep Apnea Symptoms
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Just published @NEJM Tirzepatide (GLP-1) clicks for protection vs sleep apnea in 2 randomized placebo-controlled trials: less symptoms, hypoxia, systolic BP, and reduction of inflammation by hs-CRP (w/ or w/o CPAP) https://
nejm.org/doi/full/10.10
56/NEJMoa2404881
… @AtulMalhotra13 #ADA2024 -
Polygenic Risk Scores for Type 2 Diabetes Validation
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It is high time that people know their polygenic risk score for actionable medical conditions that have been well validated across ancestries. Here's what a report should look like for Type 2 diabetes. https://
cell.com/ajhg/fulltext/
S0002-9297(24)00120-4
… -
Microbiome-Brain Connection Optimizes Mental Health Outcomes
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The brain-gut microbiome helps shape mental health and resilience to stress, "highlighting that microbiome modifications can optimize mental health." @NatMentHealth https://
nature.com/articles/s4422
0-024-00266-6
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Gestational Diabetes Management Series Published in The Lancet
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In today's @TheLancet
, there's a series of papers, including a call for action for gestational diabetes, which occurs in 14% of pregnancies, with many untoward sequelae for both mother and baby https://
thelancet.com/series/gestati
onal-diabetes
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Which Jobs Most Exposed to GPT AI LLM Impact
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You may be surprised….
Who—what jobs—are most exposed to impact of GPT #AI LLMs? https://
science.org/doi/10.1126/sc
ience.adj0998
… @ThankYourNiceAI @manlikemishap @danielrock @ScienceMagazine -
Two New Clinical Trials Published in Science Journal
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The 2 new clinical trials https://
science.org/doi/10.1126/sc
ience.ade8520
… https://
science.org/doi/10.1126/sc
ience.adf1329
… @divijmathew @andyjminn @EJohnWherry @Teijaro_Lab -
Armored CAR T cells advance cancer immunotherapy with IL-18
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We're familiar w/engineered T cells, known as CAR
Now there's Armored CAR! https://
eurekalert.org/news-releases/
1046435
… “We’ve likened this CAR T to an armored truck or tank because the release of IL 18 further protects the CAR T cells and promotes their ability to attack the cancer -
AI Breakthrough Improves Lung Cancer Survival Rates Significantly
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60% vs 8% 5-year progression-free survival (PFS). A breakthrough for a type of advanced lung cancer. https://
ascopubs.org/doi/pdf/10.120
0/JCO.24.00581
… @JCO_ASCO @ASCO @bensolomon1 -
SGLT2 Drugs Extend Lifespan via Senescent Cell Clearance
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SGLT2 drugs reduce mortality but we didn't know why. Maybe because they are senolytic, enhancing the clearance of senescent "zombie" cells https://
nature.com/articles/s4358
7-024-00642-y
… @NatureAging Lifespan in mouse model extended by this drug, not by glucose control @NatureAging