We keep ignoring CHIP (clonal hematopoiesis of indeterminate potential= mutations in our blood stem cells) even though it is no longer "indeterminate." A key marker for risk of cardiovascular events and blood cancers. It should be routinely assayed in older adults.
@erictopol
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Accelerated organ aging linked to increased mortality risk across cohorts
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The relationship of accelerated aging of organs and increased risk of mortality during 15-year follow-up in the first of 3 studies, now independently replicated and extended across multiple cohorts
Important work by @wysscoray @hammy_oh @Stanford @LudgerGoeminne @gladyshev_lab -
Ethics of Generative AI in Medicine NEJM
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At @NEJM today
A thoughtful piece on ethics of GenAI in medicine, by @Idasim and Christine Cassel @UCSFMedicine #AI https://
nejm.org/doi/full/10.10
56/NEJMp2314771
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Tracking Organ Aging: AI Insights into Internal Biological Clocks
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Our organs age at different tempo. About 1 in 5 of us are "extreme agers" for an organ.
3 recent reports highlight how we can track that and the exciting implications for these internal clocks.
In the new edition of Ground Truths (link in profile, open-access) -
AI and Genomics Predict Cancer Recurrence Beyond 10 Years
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Can we predict a cancer recurrence beyond 10 years?
"This study shows that combining genomics with artificial intelligence-aided histopathology
leads to the identification of clinical biomarkers of evolution." https://
nature.com/articles/s4301
8-024-00787-0
… @NatureCancer @AndreaSottoriva @javierfermat -
Digital Gap in Genomics and Wastewater Surveillance Systems
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While progress has been made with genomics and wastewater surveillance, digital is the big miss.
My colleague @JayPandit put together a review paper on this topic @NatureBiotech https://
nature.com/articles/s4158
7-022-01350-x
… @ScrippsRTI @scrippsresearch @GiorgioQuer -
Digital Tracking Advances Disease Transmission Assessment Beyond Contact Tracing
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One of the big missed opportunities in the pandemic was more use of digital tracking. A new @ScienceMagazine paper by @ChristoPhraser @LucaFerrettiEvo and colleagues shows its rich, real-time transmission assessment, value beyond contact tracing https://
science.org/doi/10.1126/sc
ience.adm8103
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CRISPR Screens Reveal Molecular Switch Basis for Lupus
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Discovery of a molecular switch basis for lupus (SLE) using #CRISPR screens to unravel the CXCL-13 T cell circuitry @Nature https://
nature.com/articles/s4158
6-024-07627-2
… @CalvinYLaw_ @Deepakarao @jaehyukchoimd @vwacle @NorthwesternMed -
AI Gives Doctors Gift of Time in Healthcare
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When #AI gives the gift of time https://
nytimes.com/2024/07/10/hea
lth/doctors-insurers-artificial-intelligence.html?searchResultPosition=2
… by @teddyrosenbluth the theme of Deep Medicine -
Genomics and AI Direct Successful Cancer Therapy
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How genomics + #AI can help direct successful therapy for cancer https://
nature.com/articles/s4225
6-024-00866-y
… @NatMachIntell @xlu29466