TriX Global Network with index event between 1 January 2016 and 31 March 2024. Details are in the paper and supplemental info, includes any GLP-1 drug new user for at least 6 months in people with obesity, without diabetes
@erictopol
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AI Reduces Heart Disease, Stroke, Kidney Disease Outcomes
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Other outcomes assessed. Significant reductions of ischemic heart disease (IHD), stroke, heart failure, arrhythmias, atrial fibrillation, acute and chronic kidney disease, allergic reactions
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Spatial Omics Reveals T Cells Driving Atrial Fibrillation Inflammation
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An spatial omics discovery example from this week
In the fat tissue surrounding the heart, there are resident memory T cells that promote inflammation, prominent in people with atrial fibrillation, that helps explain vulnerability to this common arrhythmia https://
nature.com/articles/s4416
1-024-00532-x
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Recent paper on maximal lifespan discussed
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We discussed his important recent paper on maximal lifespan
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Epigenetic Aging Clocks: Progress, Limitations, and Medical Promise
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Epigenetic aging clocks have become a commonly used metric in medical research and are being marketed to consumers. The new Ground Truths with @prof_horvath
, who discovered these clocks a decade ago, provides a frank appraisal of their progress, limitations, and promise. With -
LLMs Eliminate Need for Traditional Coding System Standardization
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In the era of large language models: "The extensive efforts previously required to standardize and make coding systems and ontologies interoperable for traditional computing are no longer necessary." https://
nature.com/articles/s4159
1-024-03199-w
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by @jnkath @DanielTruhn @Dykex6 @IsabellaWies -
Foundation AI Models Transform Cell Atlas Research and Perturbation Analysis
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It's one thing to have a cell atlas of the human body.
It's another to build foundation #AI models, test perturbations, and establish causal effects.
An insightful review/perspective @CellCellPress https://
cell.com/cell/fulltext/
S0092-8674(24)00829-8
… @jennyErood @GraphicAnja Aviv Regev @genentech -
Mitochondrial DNA Transfer to Brain Cells Shows Adverse Health Outcomes
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A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis") with evidence of adverse outcomes in a cohort of ~1,200 individuals https://
journals.plos.org/plosbiology/ar
ticle?id=10.1371/journal.pbio.3002723
… @PLOSBiology @ryan_e_mills @umichmedicine -
Decentralized Clinical Trials: Emerging Applications in Medical Research
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One of the first decentralized clinical trials was led by @ScrippsRTI several years ago https://
jamanetwork.com/journals/jama/
fullarticle/2687353
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Today @ScienceMagazine there's an outstanding review of the field https://
science.org/doi/10.1126/sc
ience.adq4994
… @SeixasDr @gjeanlouis1 -
Metabolic Dysfunction in Alzheimer’s Disease Treatment Innovation
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The metabolic dysfunction underpinning of #Alzheimer's disease and potential path to intervene by repurposing a drug class used in cancer (IDOI blockers) https://
science.org/doi/10.1126/sc
ience.abm6131
… @parasmin https://
science.org/doi/10.1126/sc
ience.adr5836
… @LJohnsonLab @macauleylab @ScienceMagazine