It's one thing to have a cell atlas of the human body.
It's another to build foundation #AI models, test perturbations, and establish causal effects.
An insightful review/perspective @CellCellPress https://
cell.com/cell/fulltext/
S0092-8674(24)00829-8
… @jennyErood @GraphicAnja Aviv Regev @genentech
@erictopol
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Foundation AI Models Transform Cell Atlas Research and Perturbation Analysis
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Mitochondrial DNA Transfer to Brain Cells Shows Adverse Health Outcomes
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A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis") with evidence of adverse outcomes in a cohort of ~1,200 individuals https://
journals.plos.org/plosbiology/ar
ticle?id=10.1371/journal.pbio.3002723
… @PLOSBiology @ryan_e_mills @umichmedicine -
Decentralized Clinical Trials: Emerging Applications in Medical Research
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One of the first decentralized clinical trials was led by @ScrippsRTI several years ago https://
jamanetwork.com/journals/jama/
fullarticle/2687353
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Today @ScienceMagazine there's an outstanding review of the field https://
science.org/doi/10.1126/sc
ience.adq4994
… @SeixasDr @gjeanlouis1 -
Metabolic Dysfunction in Alzheimer’s Disease Treatment Innovation
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The metabolic dysfunction underpinning of #Alzheimer's disease and potential path to intervene by repurposing a drug class used in cancer (IDOI blockers) https://
science.org/doi/10.1126/sc
ience.abm6131
… @parasmin https://
science.org/doi/10.1126/sc
ience.adr5836
… @LJohnsonLab @macauleylab @ScienceMagazine -
CHIP mutations as predictive biomarker for cardiovascular disease risk
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We keep ignoring CHIP (clonal hematopoiesis of indeterminate potential= mutations in our blood stem cells) even though it is no longer "indeterminate." A key marker for risk of cardiovascular events and blood cancers. It should be routinely assayed in older adults.
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Accelerated organ aging linked to increased mortality risk across cohorts
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The relationship of accelerated aging of organs and increased risk of mortality during 15-year follow-up in the first of 3 studies, now independently replicated and extended across multiple cohorts
Important work by @wysscoray @hammy_oh @Stanford @LudgerGoeminne @gladyshev_lab -
Ethics of Generative AI in Medicine NEJM
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At @NEJM today
A thoughtful piece on ethics of GenAI in medicine, by @Idasim and Christine Cassel @UCSFMedicine #AI https://
nejm.org/doi/full/10.10
56/NEJMp2314771
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Tracking Organ Aging: AI Insights into Internal Biological Clocks
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Our organs age at different tempo. About 1 in 5 of us are "extreme agers" for an organ.
3 recent reports highlight how we can track that and the exciting implications for these internal clocks.
In the new edition of Ground Truths (link in profile, open-access) -
AI and Genomics Predict Cancer Recurrence Beyond 10 Years
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Can we predict a cancer recurrence beyond 10 years?
"This study shows that combining genomics with artificial intelligence-aided histopathology
leads to the identification of clinical biomarkers of evolution." https://
nature.com/articles/s4301
8-024-00787-0
… @NatureCancer @AndreaSottoriva @javierfermat -
Digital Gap in Genomics and Wastewater Surveillance Systems
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While progress has been made with genomics and wastewater surveillance, digital is the big miss.
My colleague @JayPandit put together a review paper on this topic @NatureBiotech https://
nature.com/articles/s4158
7-022-01350-x
… @ScrippsRTI @scrippsresearch @GiorgioQuer