Genome editing has centered around DNA, with over 40 ongoing clinical trials and 2 FDA approvals. But RNA editing has some key advantages and appears to be taking off. An open-access review @ScienceMagazine https://
science.org/content/articl
e/buoyed-milestone-clinical-result-rna-editing-poised-treat-diseases
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@erictopol
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RNA Editing Advances Show Promise Over DNA-Based Genome Therapies
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AI Integration in Primary Care: Realistic Assessment versus Standard
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In context of the dearth of primary care physicians and serious problems with access, a realistic appraisal for how incorporating #AI in medicine should be compared to standard of care https://
nejm.org/doi/full/10.10
56/NEJMp2404691
… @NEJM @zakkohane -
LLMs’ Adverse Impact on Electronic Health Records Concerns
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Concerns about the potential adverse impact of LLMs on electronic health records @NEJM today, by @LiamGMcCoy @arjunmanrai @AdamRodmanMD https://
nejm.org/doi/full/10.10
56/NEJMp2405999
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Stem cell transplants show no increased cancer mutation risk decades later
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Reassuring: decades after stem cell transplants, no indication of increase in cancer related gene mutations https://
science.org/doi/10.1126/sc
itranslmed.ado5108
… @ScienceTM https://
nature.com/articles/d4158
6-024-03450-x
… @Nature -
Proteomics reveals non-linear aging patterns through blood protein analysis
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Two proteomic studies have found peaks of plasma proteins at different ages, which suggests that the aging process is non-linear
Links and details https://
erictopol.substack.com/p/what-can-110
00-proteins-in-our-blood
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Blood Proteins Reveal Aging and Disease Patterns Through AI
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Thousands of proteins in our blood are illuminating our pace of individual organ and body-wide biological aging, the impact of diet and lifestyle, and enabling discovery of novel cause and effect for diseases.
Reviewed in the new Ground Truths
(link in my profile, d/t -
ChatGPT Shows Better Bedside Manner Than Physicians
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In medicine, #ChatGPT and other LLMs have surprisingly and consistently been shown to promote empathy better than physicians
"You might find it disturbing that A.I. can have a better bedside manner than humans."—
@jonreismanMD @nytopinion Gift link -
Immunology Research Breakthrough in Long COVID Treatment
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For a soon to be posted Ground Truths podcast, we had a great conversation this week with Katerina, @AkassoglouLab
's recent, important @Nature paper https://
nature.com/articles/s4158
6-024-07873-4
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Helpful Figure below from https://
cell.com/trends/immunol
ogy/abstract/S1471-4906(24)00211-4?_returnURL=httpslinkinghub.elsevier.comretrievepiiS1471490624002114showalltrue
… #LongCovid -
Senescent Cells Removal: Balancing Benefits Against Aging
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There's keen interest in getting rid of senescent cells in the body to slow the aging process. One little problem: there are many types of these cells, some are quite beneficial, essential for repair or regeneration https://
cell.com/cell/fulltext/
S0092-8674(24)01069-9
… @CellCellPress -
AI Enables Non-Invasive Gut Microbiome Diagnosis
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Until now, the gut microbiome hasn't been used to make clinical diagnoses. That may change. A new report on its utility for non-invasively diagnosing inflammatory bowel disease. https://
nature.com/articles/s4159
1-024-03280-4
… @NatureMedicine @Siew_C_Ng