Genome sequencing of healthy people finds 2-5% unknowingly harbor important, actionable, disease- causing gene mutations. A new report @MountSinaiNYC adds to previous studies https://
cell.com/cell-reports-m
edicine/fulltext/S2666-3791(24)00187-3?_returnURL=httpslinkinghub.elsevier.comretrievepiiS2666379124001873showalltrue
… @IainSForrest @IcahnMountSinai @DoGenetics
@erictopol
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Genome sequencing reveals actionable disease mutations in healthy people
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KRAS Cancer Mutations Now Druggable With AI Advances
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Not many years ago we had no treatments vs KRAS driver mutations for cancer. Considered undruggable. Now look! https://
nature.com/articles/s4159
1-024-02903-0
… @NatureMedicine @EileenMOReilly @MSKCancerCenter -
Polygenic Risk Scores Enhance Coronary Disease Risk Assessment
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Evidence for why a polygenic risk score for coronary artery disease, in conjunction with clinical risk factors, provides useful individualized risk assessment https://
cell.com/med/abstract/S
2666-6340(24)00087-4?_returnURL=httpslinkinghub.elsevier.comretrievepiiS2666634024000874showalltrue
… @pnatarajanmd @buutrg @Cell_Med -
Immunocompromised Patient Fights 613-Day Chronic COVID Battle
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An immunocompromised individual has had chronic Covid for >613 days, requiring multiple hospital admissions
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Liver immune tolerance mechanism offers cancer therapy breakthrough
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The liver can be a path towards establishing immune tolerance for autoimmune diseases. But it also promotes immune evasion of cancer. A mechanism for this is identified here and could prove useful for directing therapy https://
nature.com/articles/s4159
0-024-01820-1
… @NatImmunol @LabBeatty @PennMedicine -
LLMs Achieve Expert-Level Ophthalmological Knowledge and Reasoning
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"Large language models (LLMs) are approaching expert-level ophthalmological knowledge and reasoning" https://
journals.plos.org/digitalhealth/
article?id=10.1371/journal.pdig.0000341
… @PLOSDigiHealth -
New LLM Primer Book Offers Practical Usage Tips
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My friend @emollick assesses large language models as deeply as anyone, and his primer book, coming out this week, is chock full of useful tips for how to use them. And I love the title.
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ECPR procedure achieves near-perfect cardiac arrest revival rates
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"Patients with certain types of cardiac arrest who are treated with a new procedure, called ECPR, have a nearly 100 % chance of being revived, with their brain function intact, if treatment is administered within 30 minutes of collapse." https://
nytimes.com/2024/03/27/mag
azine/ecpr-cardiac-arrest-cpr.html?pgtype=Article&action=click&module=RelatedLinks
… @DrHelenOuyang -
Dr. Siddartha Mukherjee on AI, Longevity, and Disease Prevention
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When @DrSidMukherjee goes off script, things get quite interesting!
Our conversation on #AI, longevity, and preventing diseases.
In the new Ground Truths (link in profile) -
CD19 Treatment for Multiple Sclerosis Enters Human Clinical Trials
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This promising CD19 treatment for autoimmune diseases now being tested in multiple sclerosis for the first time in 2 patients https://
cell.com/med/fulltext/S
2666-6340(24)00114-4
… @MedCellPress