Nice lede https://
nature.com/articles/s4159
1-024-02860-8
… @NatureMedicine "The 2019 Topol Review for the UK National Health Service (NHS) outlined a vision for a digital future for healthcare."
by @Sheena_Visram @njsebire Yvonne Rogers
@erictopol
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NHS Digital Future: AI Healthcare Transformation Vision
By
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PD-1 Receptor Dimer Structure Offers New Autoimmune Disease Treatment
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@SciImmunology Contrary to science dogma, the programmed cell death (PD-1) receptor on immune cells exists as a dimer (not just as a monomer). Its stimulation (checkpoint agonist) may be well suited to treat/prevent autoimmune diseases https://
science.org/doi/10.1126/sc
iimmunol.ade6256
… @Elliot_Philips -
Y Chromosome Loss Triggers Epigenetic Switch in Heart Macrophages
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@NatureCVR The loss of Y chromosome in older men is associated with heart failure, but the mechanism is unknown. As determined via single-cell omics, an epigenetic switch occurs for heart macrophages to become pro-fibrotic https://
nature.com/articles/s4416
1-024-00439-7
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Generative AI Accelerates Fibrosis Drug to Clinical Trials
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Thanks to generative #AI, a drug that counters fibrosis (scarring), and possibly modulates the tissue aging process, with its mechanism elucidated, has been rapidly advanced to clinical trials for IPF https://
nature.com/articles/s4158
7-024-02143-0
… @NatureBiotech @biogerontology @InSilicoMeds -
AI Skin Cancer Apps Lack FDA Approval and Validation
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A new review of >40 #AI smartphone DTC apps for skin conditions and cancer detection highlights lack of FDA approval, validation, misleading user communication and potential for harm https://
jamanetwork.com/journals/jamad
ermatology/fullarticle/2815800
… by @wshannon_w @Dr_vron @RoxanaDaneshjou and colleagues @JAMADerm -
CHIP Clonal Hematopoiesis Now Has Determined Clinical Potential
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CHIP stands for clonal hematopoiesis of indeterminate potential. But it's no longer "indeterminate," as exemplified by this report, and needs a new abbreviation @NatureMedicine by @DrFlashHeart @AlexBickMDPhD and colleagues
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AI predicts disease risk decades in advance using unsupervised learning
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Predicting a person's life risk of diseases many decades ahead with unsupervised #AI @CSHVienna @ElmaDervicMe @MedUni_Wien @Nature_NPJ https://
nature.com/articles/s4174
6-024-01015-w
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NEJM Review Table of Healthcare AI Interventions
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In the new @NEJM review I cited there is a Table of things that can be done
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Blood Test Creates Alzheimer’s Diagnosis in Healthy People
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How a blood test (p-Tau217) and drugs that have little efficacy (and major side effects) are creating "#Alzheimers Stage 1" in healthy people with no symptoms or memory deficit https://
latimes.com/science/story/
2024-02-14/inside-controversial-plan-to-diagnose-alzheimers-in-people-without-symptoms
… @MelodyPetersen @latimes @alzassociation -
Protein Design Breakthrough: AI Transforms Biology Three Years Post-AlphaFold2
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3 years after the #AlphaFold2 moment, we've never been in a better position to design new proteins, antibodies, enzymes, and vaccines from scratch, thanks to transformer and diffusion #AI models
Dedicated new issue @NatureBiotech w/ primers & reviews https://
nature.com/nbt/volumes/42
/issues/2
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