My favorite books, 2024
by @emollick @firstadopter @anilananth @harari_yuval @carlzimmer and other great authors not on X
@erictopol
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Favorite Books 2024 by Tech Influencers and Authors
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GLP-1 drugs show anti-inflammatory effects independent weight loss
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Two new studies zero in on the anti-inflammatory effects of the GLP-1 family of drugs, independent of weight loss, highlighting the gut-brain axis (modulating TLR response) and the gut GIP impact
by @DanielJDrucker and colleagues https://
cell.com/cell-metabolis
m/fulltext/S1550-4131(23)00420-5
… @Cell_Metabolism -

AI Predicts Immunotherapy Success in Advanced Lung Cancer
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From a single path slide, how #AI could help predict the success of immunotherapy in patients with an advanced type of lung cancer https://
jamanetwork.com/journals/jamao
ncology/fullarticle/2828578?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamaoncol.2024.5356
… @JAMAOnc -
AI and continuous glucose sensors differentiate Type 2 diabetes dysregulation
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The potential for using continuous glucose sensors and #AI to differentiate types of glucose dysregulation in people with Type 2 diabetes or pre-diabetes https://
nature.com/articles/s4155
1-024-01311-6
… @NatBME @Snyder_Lab_SU -

COVID-19 Spike Protein Triggers Pancreatic Islet Microvascular Dysfunction
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Covid is associated with an increased risk of Type 2 diabetes https://
thelancet.com/journals/landi
a/article/PIIS2213-8587(24)00159-1/fulltext
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(one of many reports) But the mechanism is unclear. A new study suggests islet microvascular dysfunction is a contributing factor https://
diabetesjournals.org/diabetes/artic
le/doi/10.2337/db24-0816/157642/SARS-CoV-2-Spike-S1-subunit-triggers-pericyte-and
… open-access -
AI Unlocking Life’s Secrets for Medical Breakthroughs
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A.I. as unlocking life’s deepest secrets and establishing a powerful new basis for curing ills, improving health and lengthening lives.
"Once we decipher and truly understand the language of life, it will be magical."—
@pushmeet -

The upside of AI hallucination in scientific research
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The upside of #AI hallucination gift link https://
nytimes.com/2024/12/23/sci
ence/ai-hallucinations-science.html?unlocked_article_code=1.j04.dJai.yeEAdu9_jlQn&smid=url-share
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by @WilliamJBroad @NYTScience -
AI breakthrough enables insulin-free diabetes management in young woman
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Good summary of this important advance in a 25-year-old woman with Type 1 diabetes -> insulin-free
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Brain-Immune System Axis: Three Rheostats for Control
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Featuring 3 different rheostats that can dial up or down the brain-body immune system axis. One of them is from this week's @ScienceMagazine https://
science.org/doi/10.1126/sc
ience.adl4237
… https://
erictopol.substack.com/p/guardians-of
-the-brain
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Deep Visual Proteomics Enables Breakthrough Treatment for Toxic Epidermal Necrolysis
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Commentary by @NordmannThierry @labs_mann @MundAndreas on Deep Visual Proteomics, the transformative innovation used to identify a successful treatment for patients with toxic epidermal necrolysis