Discovery of the specialized brain cells that convey and regulate hunger/satiety
The cells integrate input of food (visual, smell, texture) and gut hormone circuitry. Another jump forward through spatial omics. https://
cell.com/cell/fulltext/
S0092-8674(25)00047-9
… @CellCellPress @cpnoc @Columbia
@erictopol
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Brain cells regulating hunger discovered via spatial omics
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GPT-4 Enhances Physician Performance in Clinical Care Tasks
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A randomized trial of GPT-4 vs 92 physicians with or without this #AI LLM for performance on patient care tasks.
AI improved physician performance, on par with AI alone (based on 5 clinical vignettes) https://
nature.com/articles/s4159
1-024-03456-y
… @NatureMedicine @AdamRodmanMD @jonc101x -
GLP-1 Drug Exenatide Fails to Improve Parkinson’s Disease Progression
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New @TheLancet Exenatide, a GLP-1 drug failed to improve #Parkinsons disease motor features (or slow progression) vs placebo in a small Phase 3 randomized, controlled trial https://
thelancet.com/journals/lance
t/article/PIIS0140-6736(24)02808-3/fulltext
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Researcher Demonstrates Scientific Integrity Through Personal Practice
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Good explainer @nature https://
nature.com/articles/d4158
6-025-00355-1
…
"I practice what I publish" —
@prof_horvath -
MicroRNAs: From Cancer Roles to Longevity Enhancement
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MicroRNAs
From their role in cancer https://
jci.org/articles/view/
189625to
… @jclinicalinvest to
Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity https://
sciencedirect.com/science/articl
e/pii/S1550413124004819?viaihub
… @Cell_Metabolism explainer https://
nature.com/articles/d4158
6-025-00032-3
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Master of Digital Health Degree Development in JAMA
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Our essay today @JAMA_current for why we should develop a Master of Digital Health (MDH) degree https://
jamanetwork.com/journals/jama/
fullarticle/2829319
… a joy to collaborate with @ejosipcar on this -
ESM3 Release: Advanced Protein Structure Prediction Explainer
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Great explainer of significance @EvoscaleAI https://
evolutionaryscale.ai/blog/esm3-rele
ase
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Large Language Model Generates Protein Equivalent to 500 Million Years Evolution
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Whoa! When a large language of life model generates a protein equivalent to ~500 million years of evolution. @ScienceMagazine http://
science.org/doi/10.1126/sc
ience.ads0018
… @THayes427 @proteinrosh @EvoscaleAI @arcinstitute @UCBerkeley -
Genomic Loci Association with Type 2 Diabetes Reviewed
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The multitude of genomic loci that are associated with Type 2 diabetes, nicely reviewed @TheLancetEndo by @philippefroguel and colleagues https://
thelancet.com/journals/landi
a/article/PIIS2213-8587(24)00339-5/abstract
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Multimodal AI Predicts Cancer Risk Using Proteomics and Health Records
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Using multimodal A.I. to more accurately predict a person's risk of cancer (and other conditions) by combining proteomics and electronic health records https://
nature.com/articles/s4225
6-024-00974-9
… @NimaAghaeepour @NatMachIntell open-access