In the post-AlphaFold era, drug discovery is on a tear
—Genome-wide virtual screening @ScienceMagazine https://
science.org/doi/10.1126/sc
ience.ads9530
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—Transforming the industry in many ways @TheEconomist https://
economist.com/leaders/2026/0
1/08/ai-is-transforming-the-pharma-industry-for-the-better?utm_content=ed-picks-image-link-3&etear=nl_weekly_3&utm_campaign=r.the-economist-this-week&utm_medium=email.internal-newsletter.np&utm_source=salesforce-marketing-cloud&utm_term=1/8/2026&utm_id=2153721
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@erictopol
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AlphaFold revolutionizes drug discovery through genome-wide virtual screening
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Thymus Rejuvenation Strategy Preserves Immune System in Aging
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Rejuvenating the thymus is another strategy to preserve an intact immune system with advanced aging
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Collider Bias Critique in AI Research Methodology
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Critique of the paper based on collider bias https://
zenodo.org/records/180021
86
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Sleep vs Exercise: Impact on Epigenetic Aging and Healthspan
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Agree on healthspan extension, but sleep hasn't been shown to change epigenetic age and hallmarks of aging like exercise
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Natural Killer Cells: Emerging Therapeutic Potential Beyond Cancer Treatment
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Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review @JExpMed https://
rupress.org/jem/article/22
3/1/e20250612/278584/Bringing-natural-killer-cells-to-the-clinic
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Oura Ring CEO Proposes New FDA Regulatory Path Digital Health
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The CEO of @ouraring proposes a new FDA regulatory path for wearable sensors—"digital health screeners" @tomeghale What do you think of this idea? https://
wsj.com/opinion/with-l
ess-regulation-your-oura-ring-could-do-more-af90a76d?st=Wjduif&reflink=desktopwebshare_permalink
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AI Reveals Amyloid-Beta Feedback Loop in Alzheimer’s Pathogenesis
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The amyloid-β feedback loop and pathogenesis of Alzheimer's disease
when aggregates form, the shift from protecting/building synapses to destroying them @jclinicalinvest https://
jci.org/articles/view/
200393
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Physician Role Transformation in Democratized Information Era
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The changing role of physicians in the era of democratizing information and knowledge https://
newyorker.com/culture/2025-i
n-review/the-role-of-doctors-is-changing-forever
… by @DhruvKhullar @NewYorker -
Achieving Peak Human Performance Across Multiple Domains
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What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @ScienceMagazine https://
science.org/doi/10.1126/sc
ience.adt7790
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AI Imaging Advances in Coronary Artery Disease Detection
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A new, outstanding review of non-invasive imaging for coronary artery disease —"Most acute coronary syndromes occur in arterial segments with non-obstructive disease, which can be appreciated on CT coronary angiography but not on functional tests only detecting ischemia."