This connects well with epigenetic dysregulation that drives the aging process, subject of a new and topnotch review https://
nature.com/articles/s4158
0-026-00958-0
… @gladyshev_lab
@erictopol
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Epigenetic Dysregulation Drives Aging Process Review
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Heart-Brain Axis: Atrial Fibrillation Impact on Brain Glymphatic Flow
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Heart-Brain Axis
Atrial fibrillation leads to reduced brain glymphatic flow, decreased washout of waste metabolites. https://
academic.oup.com/eurheartj/arti
cle/46/18/1733/8029578?login=false
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Today #ACC26 @JAMACardio Serum Neurofilament (sNfl), a marker for brain cell injury, is associated with adverse CV events and mortality in -
Artificial Biological Intelligence: Genome Writing and Species Future
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Artificial Biological Intelligence (ABI) In a post-Darwinian era of being able to write genomes, the implications—both for good and harm—are profound. In conversation with @AdrianWoolfson on his new book On the Future of Species https://
erictopol.substack.com/p/on-the-futur
e-of-species
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AI Sycophancy Problem Addressed in New Science Magazine Research
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The problem of AI sycophancy addressed in the new issue: @ScienceMagazine cover and original research by @chengmyra1 and colleagues https://
science.org/doi/10.1126/sc
ience.aec8352
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AI Scientist article heralds new era for scientific discovery
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The AI Scientist, a new @Nature article making the case:
"The dawn of a new era in which the process of discovery is no longer a solely human pursuit and in which the pace at which we are able to reap the harvest of scientific discovery could accelerate dramatically." -
AI Matches 50 Dermatologists in Melanoma Diagnosis Accuracy
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How good is AI for diagnosing melanoma?
A systematic review of 11 studies, 2500 patients, finds accuracy and performance comparable to 50 dermatologists, with promise for broad use requiring further validation @JAMADerm This is important with the big shortage of dermatologists -
Radiologists and AI fail to spot deepfake medical scans.
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The majority of radiologists and 4 LLMs were unable to differentiate synthetic, deepfake scans from real ones https://
pubs.rsna.org/doi/10.1148/ra
diol.252094
… @RSNA -
Agentic AI and Intelligence Explosion Essay
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"The recent explosion of agentic AI suggests the possibility of something similar at the scale of billions of interacting minds, human and non-human alike."
An essay on the Intelligence Explosion @ScienceMagazine by @profjamesevans @bratton @blaiseaguera -
AI to understand the language of life in Nature Biotechnology
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AI to understand the language of life.
Our review @NatureBiotech just published https://
nature.com/articles/s4158
7-026-03064-w
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Free access https://
rdcu.be/e89lQ @VishRao5 @serena2z @BrianPlosky @pdhsu @BoWang87 @james_y_zou @marinkazitnik @pranavrajpurkar -
Sam Altman’s Firing: Not About AI Safety, Says Testimony
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Questioning the benefit of an implant to close the left atrial appendage vs medical therapy in a randomized trial @NEJM https://
nejm.org/doi/full/10.10
56/NEJMoa2513310?query=featured_home
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