Just published @NatureMedicine Randomized trial of tirzepatide (Mounjaro) vs placebo *after* 12 weeks of intensive lifestyle intervention and >5% weight loss https://
nature.com/articles/s4159
1-023-02597-w
…
At 72 weeks, Placebo group gained 2.5% weight back; GLP-1 drug lost additional 18.4% body weight
@erictopol
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Tirzepatide outperforms placebo in weight loss clinical trial
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CRISPR Genome Editing: Where Science Fiction Becomes Reality
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"It sounds science fictional except it's science real."—
@UrnovFyodor Where are we heading with #CRISPR genome editing? https://
erictopol.substack.com/p/on-genome-ed
iting-with-fyodor-urnov#details
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Academic Spinouts Advance Vaccine Development with $800M Support
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Key points of progress
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@florian_krammer and @MountSinaiNYC spinout @castlevaxbio —
@stonybrooku spinout @Codagenix —6-proline substitution discovery @McLellan_Lab —Prime and spike @VirusesImmunity @YaleIBIO @YaleCII —up to ~$800 million support by @HHSGov -
Nobel Prize and the Future of Vaccines Innovation
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As mentioned in the segment, this conversation was an outgrowth of a recent Ground Truths post https://
erictopol.substack.com/p/a-nobel-priz
e-and-the-future-of-vaccines
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Covid vaccines expand beyond infectious diseases with nasal approach
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On the new @scifri
, I spoke with @iraflatow on the exciting new directions that Covid vaccines have taken us, well beyond infectious diseases. And a nasal vaccine vs 3 pathogens (mumps, measles and Covid)! -
Black Women Faculty Representation in US Medical Schools
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As of last year's data for US medical schools @AAMCtoday
, only 0.9% of full professors are Black women. Here's the story of @gradydoctor
's promotion and what it means. Congrats Kimberly! https://
thelancet.com/journals/lance
t/article/PIIS0140-6736(23)02232-8/fulltext
… @TheLancet @EmoryUniversity @EmoryMedicine -
HHS funds clinical trials for Covid nasal vaccines
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The United States
@HHSGov
Project NextGen gives large awards to support clinical trials of 2 Covid nasal vaccines https://
cnn.com/2023/10/13/hea
lth/hhs-project-nextgen-covid/index.html
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Fyodor’s CRISPR Gene Editing Opinion in New York Times
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Oops. I meant @UCBerkeley
— Eric Topol (@EricTopol) 12 octobre 2023
Here's a snippet on Fyodor's oped @nytopinion and the link to ithttps://t.co/tGlzhGivDV pic.twitter.com/7PyetUsvfVOops. I meant @UCBerkeley Here's a snippet on Fyodor's oped @nytopinion and the link to it https://
nytimes.com/2022/12/09/opi
nion/crispr-gene-editing-cures.html
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Bacteria Combined with CAR-T Cells Treats Solid Tumors
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Engineering T cells to help treat blood ("liquid") cancers has been quite successful, but solid tumors represent a formidable challenge. Combining bacteria with CAR-T may overcome it https://
science.org/doi/full/10.11
26/science.adk6098
… https://
science.org/doi/10.1126/sc
ience.add7034
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AI Enables 3D Brain MRIs in 10 Minutes at Lower Power
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Enabled by #AI
3D Brain MRIs in 10 minutes
and at 0.05 tesla instead of 1.5 or 3 T