What happens with the proteins in blood in people with #LongCovid vs matched healthy controls, with or without recovery, and over time? https://
thelancet.com/action/showPdf
?pii=S2352-39642300417-6
…
@erictopol
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Blood Protein Changes in Long Covid Patients: Clinical Study Analysis
By
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Brain-Heart Pathway Mechanism for Syncope Discovered Using Advanced Techniques
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Discovery of a brain-heart pathway mechanism for syncope (fainting), underpinning the reflex first described by Bezold in 1867 (later known as Bezold-Jarisch reflex) https://
nature.com/articles/d4158
6-023-03076-5
… https://
nature.com/articles/s4158
6-023-06680-7
…
elegant work w/ scRNA-seq, #optogenetics @vinnyaug1 @UCSD -
GLP-1 Drug Hype: Wall Street’s Irrational Exuberance Questioned
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The out-of-control, irrational exuberance that GLP-1 drugs will end Type-2 diabetes, liver (NASH, NAFLD)) and heart disease, among other projections And no, they are not "the #AI of healthcare" https://
wsj.com/finance/stocks
/the-ozempic-effect-on-wall-street-has-gone-overboard-2ce5e055?mod=Searchresults_pos1&page=1
… by @CGrantWSJ and @david_wainer -
Cancer cells hijack mitochondria from T cells: metabolic warfare
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Did you know that cancer cells can hijack mitochondria from T cells? Metabolically empowering the former, depleting the latter. And it's associated with poor clinical outcomes. Another insight of single-cell resolution work @Cancer_Cell https://
cell.com/cancer-cell/pd
fExtended/S1535-6108(23)00319-7?utm_campaign=morning_rounds&utm_medium=email&_hsmi=278149414&_hsenc=p2ANqtz-_Mbg84VMXeTDy4qk3v_VA86P8BpnyxzDuSkFOA3QQcd32kYmRJtA_XPwsy_JeMTCbMe07nNC-WyI7oLRDPBpvqKRL-aQ&utm_content=278149414&utm_source=hs_email
… -
Tirzepatide outperforms placebo in weight loss clinical trial
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Just published @NatureMedicine Randomized trial of tirzepatide (Mounjaro) vs placebo *after* 12 weeks of intensive lifestyle intervention and >5% weight loss https://
nature.com/articles/s4159
1-023-02597-w
…
At 72 weeks, Placebo group gained 2.5% weight back; GLP-1 drug lost additional 18.4% body weight -
CRISPR Genome Editing: Where Science Fiction Becomes Reality
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"It sounds science fictional except it's science real."—
@UrnovFyodor Where are we heading with #CRISPR genome editing? https://
erictopol.substack.com/p/on-genome-ed
iting-with-fyodor-urnov#details
… -
Academic Spinouts Advance Vaccine Development with $800M Support
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Key points of progress
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@florian_krammer and @MountSinaiNYC spinout @castlevaxbio —
@stonybrooku spinout @Codagenix —6-proline substitution discovery @McLellan_Lab —Prime and spike @VirusesImmunity @YaleIBIO @YaleCII —up to ~$800 million support by @HHSGov -
Nobel Prize and the Future of Vaccines Innovation
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As mentioned in the segment, this conversation was an outgrowth of a recent Ground Truths post https://
erictopol.substack.com/p/a-nobel-priz
e-and-the-future-of-vaccines
… -
Covid vaccines expand beyond infectious diseases with nasal approach
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On the new @scifri
, I spoke with @iraflatow on the exciting new directions that Covid vaccines have taken us, well beyond infectious diseases. And a nasal vaccine vs 3 pathogens (mumps, measles and Covid)! -
Black Women Faculty Representation in US Medical Schools
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As of last year's data for US medical schools @AAMCtoday
, only 0.9% of full professors are Black women. Here's the story of @gradydoctor
's promotion and what it means. Congrats Kimberly! https://
thelancet.com/journals/lance
t/article/PIIS0140-6736(23)02232-8/fulltext
… @TheLancet @EmoryUniversity @EmoryMedicine