How can we rejuvenate memory T cells in older adults?
@erictopol
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RUNX1 Factor Enables T Cell Rejuvenation in Aging Adults
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Discovery of a factor (RUNX1) that pinpoints T cell senescence and restoring its functionality achieves T cell rejuvenation. Significant implications in older adults with loss of immune system protection. https://
cell.com/immunity/abstr
act/S1074-7613(26)00077-4
… @ImmunityCP -
P-tau217 biomarker predicts Alzheimer’s disease in older adults
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Another study indicative of predictive power of p-tau217 for Alzheimer's disease in cognitively unimpaired older adults (mean age 71 at baseline) A very low p-tau217 denoted minimal risk https://
nature.com/articles/s4146
7-026-71269-3
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First AI Drug Prescriber: Utah Company Doctronic Milestone
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An editorial @JAMA_current on @doctronic (the AI company now prescribing renewal medications without physician involvement in Utah) entitled "The First AI Drug Prescriber" https://
jamanetwork.com/journals/jama/
article-abstract/2847569
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LLMs Assessment for Clinical Diagnosis: Safety and Reasoning Limitations
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Assessment of 21 LLMs for generating a differential diagnosis
"Off-the-shelf LLMs have not yet achieved the intelligence required for safe deployment and
remain limited in demonstrating advanced clinical reasoning." https://
jamanetwork.com/journals/jaman
etworkopen/fullarticle/2847679?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamanetworkopen.2026.4003
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Genetic editing breakthrough transforms rare disease treatment paradigm
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The turning point for rare diseases, which affect >300 million people around the world.
A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments
gift link: https://
nytimes.com/2026/04/09/opi
nion/genetic-editing-diseases-health-care.html?unlocked_article_code=1.aVA._Ngc.rcD9QiLWrfIM&smid=url-share
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AI Needed for Parkinson’s Disease Treatment Breakthrough
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It's World Parkinson's Day and we still have no disease-modifying drug or prevention for this condition, the 2nd most common and fastest growing neurodegenerative disease. That needs to change! https://
nature.com/articles/s4158
2-024-01034-x
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Spatial Medicine Saves Lives: AI Healthcare Innovation
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We've already seen spatial medicine save lives https://
erictopol.substack.com/p/the-dawn-of-
spatial-medicine
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Spatial Biology and AI Advancing Personalized Cancer Immunotherapy
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Towards Spatial Medicine for individualized cancer immunotherapy @SciImmunology "The convergence of spatial biology platforms, single-cell immune profiling, and machine learning is positioning the community to decode how T cell immunity is spatially organized in human tissues
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AI’s Best Use Case: Improving Human Health
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"The best use case of AI is to improve human health"—
@demishassabis