More sequence-structure co-design brings a happy tear to my eye https://t.co/ScQ0mhsA6e
— Jason Yim (@json_yim) 8 avril 2026
More sequence-structure co-design brings a happy tear to my eye Jarrid Rector-Brooks (@jarridrb) What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬 Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design 14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry. DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure. 📝 Blog: disco-design.github.io/ 📄 Paper: arxiv.org/abs/2604.05181 💻 Code: github.com/DISCO-design/DISC… — https://nitter.net/jarridrb/status/2041893841301860542#m