Whether it’s screening semiconductor materials or exploring drug-protein interactions, computational scientists hit the same wall: workflow friction and inefficiency. But modelling complex molecular phenomena shouldn't feel like a battle.
SOFTWARE
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kUPS: Molecular Simulation Engine for AI Workflows
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Today at @iclr_conf 2026, I was excited to announce kUPS: a molecular simulation engine built for the AI era, optimized for GPU in collaboration with NVIDIA. kUPS is a plug-and-play, Python-native toolkit designed to integrate seamlessly with modern ML workflows.
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Codex 5.5 Expands AI Assistance Beyond Coding Tasks
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Codex + 5.5 is incredible for the full spectrum of computer use. No longer just for coders, but for anyone who does computer work (including creating spreadsheets, slides, etc). https://t.co/Jy8oFQSiqs
— Greg Brockman (@gdb) 23 avril 2026Codex + 5.5 is incredible for the full spectrum of computer use. No longer just for coders, but for anyone who does computer work (including creating spreadsheets, slides, etc).
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Codex Used for Security Reviews of AI-Generated Code
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I've been previewing this in Codex for a few weeks – it's very good!
— Simon Willison (@simonw) 23 avril 2026
Had some great results from it having it run security reviews against code written using other models https://t.co/MHVbOboODqI've been previewing this in Codex for a few weeks – it's very good! Had some great results from it having it run security reviews against code written using other models
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AI Helps Build Apps for E-Readers and Flipper Zero
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So it can basically understand how to build apps and tools for anything you throw at it. For example, I recently bought this device, a small e-reader. It fully understood the firmware, and now I am making apps for it! Or even making full apps/games for my Flipper Zero.
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GPT-5.5 Achieves State-of-the-Art Agentic Coding and Tool Use Results
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GPT-5.5 reaches SOTA results across key evals for agentic coding, computer use, tool use, advanced math, and cybersecurity: 82.7% on Terminal-Bench 2.0 and 78.7% on OSWorld-Verified. Rolling out in Codex and ChatGPT today. API coming soon! Full post:
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Early Access to GPT-5.5 Pro Version Announced
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I had early access to GPT-5.5. It is very good, especially the Pro version. Full writeup very shortly.
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Latest App Version Now Available for Windows Download
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It's out and supported in windows – download the latest version of the app!
— Vaibhav (VB) Srivastav (@reach_vb) 23 avril 2026
demo by @bsch93841 🔥 pic.twitter.com/7lrr1m0Q3OIt's out and supported in windows – download the latest version of the app! demo by @bsch93841
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API Pricing Announcement: $5 per Million Input Tokens
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API pricing will be $5 per 1 million input tokens and $30 per 1 million output tokens, with a 1 million context window. (Remember, you will need less tokens per task than 5.4!)
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New AI Model Launches Today: Faster, More Token-Efficient
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It is smart and fast; per-token speed matches 5.4 and it uses significantly fewer tokens per task. In my experience, it "gets what to do". Rolling out today in ChatGPT and Codex. We are working with API customers on security and safeguards and plan to launch in API very soon.