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Structure-Leveraging Optimization for Efficient Protein Design

Data-driven optimization works best when we can leverage structure. In offline RL, MDP structure enables temporal compositionality ("stitching"), while for protein design, analogous graph structure can make design of new proteins more efficient! James Bowden (@jamesbowden_) I'm excited to share our ICLR paper on how leveraging decomposability can enable more efficient scientific design, with @jlistgarten and @svlevine. We were motivated by protein design in particular. Check out the blog post: james-bowden.github.io/dado/. — https://nitter.net/jamesbowden_/status/2035457915428233479#m

→ View original post on X — @berkeley_ai, 2026-03-21 21:18 UTC